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March 17 - 2020

Activation of innate immunity by 14-3-3 epsilon, a new potential alarmin in osteoarthritis (Équipe Berenbaum) M. Millerand, L. Sudre, M. Nefla, F. Pène, C. Rousseau, A. Pons, A. Ravat, G. André-Leroux, S. Akira, T. Satoh, F. Berenbaum, C. Jacques

Osteoarthritis Cartilage. 2020;28(5):646-57 OBJECTIVE : The innate immune system plays a central role in osteoarthritis (OA). We identified 14-3-3epsilon as a novel mediator that guides...

September 20 - 2020

Jejunum: The understudied meeting place of dietary lipids and the microbiota (Équipe Seksik - Sokol ) Ingrid Lema, Joao Ricardo Araujo, Nathalie Rolhion, Sylvie Demignot

Biochimie. 2020;178:124-36 Although the jejunum is the main intestinal compartment responsible for lipid digestion and absorption, most of the studies assessing the impact of dietary lipids...

June 01 - 2020

Clearing method for 3-dimensional immunofluorescence of osteoarthritic subchondral human bone reveals peripheral cholinergic nerves (Équipe Berenbaum) Alice Courties, Morgane Belle, Simge Senay, Adeline Cambon-Binder, Alain Sautet, Alain Chédotal, Francis Berenbaum, Jérémie Sellam

Sci Rep. 2020;10(1):8852 The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA)...

September 19 - 2020

The Gut Microbiota at the Service of Immunometabolism (Équipe Seksik - Sokol) Chloé Michaudel, Harry Sokol

Cell Metab. 2020;32(4):514-23 The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of...

June 04 - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty) Yishan Ye, Béatrice Gaugler, Mohamad Mohty, Florent Malard

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...

September 29 - 2020

Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity (Équipe Seksik - Sokol) Garance Coquant, Jean-Pierre Grill, Philippe Seksik

Front Immunol. 2020;11:1827 Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the...

August 30 - 2020

Linking Strain Engraftment in Fecal Microbiota Transplantation With Maintenance of Remission in Crohn's Disease (Équipe Seksik - Sokol) Lingjia Kong, Jason Lloyd-Price, Tommi Vatanen, Philippe Seksik, Laurent Beaugerie, Tabassome Simon, Hera Vlamakis, Harry Sokol, Xavier J Ramnik

Gastroenterology. 2020;159(6):2193-202 e5 BACKGROUND & AIMS : Crohn's disease (CD) is a chronic gastrointestinal disease resulting from the dysfunctional interplay between genetic...

December 05 - 2020

Gut microbiota-derived metabolites as central regulators in metabolic disorders (Équipe Seksik - Sokol) Allison Agus, Karine Clement, Harry Sokol

Gut. 2020 Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with...

December 17 - 2020

Anti-Inflammatory Effects of Analogues of N-Acyl Homoserine Lactones on Eukaryotic Cells (Équipe Seksik - Sokol) Agathe Peyrottes, Garance Coquant, Loic Brot, Dominique Rainteau, Philippe Seksik, Jean-Pierre Grill, Jean-Maurice Mallet

Int J Mol Sci. 2020;21(24) BACKGROUND : Since acyl-homoserine lactone (AHL) profiling has been described in the gut of healthy subjects and patients with inflammatory bowel disease (IBD),...

December 11 - 2020

Introduction to host microbiome symbiosis in health and disease (Équipe Mohty) Florent Malard, Joel Dore, Beatrice Gaugler, Mohamad Mohty

Mucosal Immunol. 2020 Humans share a core intestinal microbiome and yet human microbiome differs by genes, species, enterotypes (ecology), and gene count (microbial diversity). Achievement...

December 02 - 2020

Tryptophan Metabolism as a Pharmacological Target (Équipe Seksik - Sokol) Morgane Modoux Nathalie Rolhion Sridhar Mani Harry Sokol

Trends Pharmacol Sci. 2020 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many...

July 31 - 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19 (Équipe Dorothée) Mireille Laforge, Carole Elbim, Corinne Frere, Miryana Hemadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker

Nat Rev Immunol. 2020;20(9):515-6 The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species...

February 03 - 2021

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology (Équipe Dorothée) Iain J. Hartnell, David Blum, James A.R. Nicoll, Guillaume Dorothée, Delphine Boche

Brain. 2021 Neuroinflammation is involved in the aetiology of many neurodegenerative disorders including Alzheimer's disease, Parkinson's disease and motor neuron disease. Whether...

April 28 - 2020

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma (Équipe Housset) Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau

ACS Nano. 2020;14(5):5738-53 Physical oncology recognizes tissue stiffness mediated by activation of cancer-associated fibroblasts (CAF) and extracellular matrix remodeling as an active...

February 12 - 2021

Tryptophan metabolites get the gut moving (Équipe Seksik - Sokol ) Nicolas Benech, Nathalie Rolhion, Harry Sokol

Cell Host Microbe. 2021;29(2):145-7 How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host &...

April 29 - 2021

Recipient factors in faecal microbiota transplantation: one stool does not fit all (Équipe Seksik - Sokol) Camille Danne, Nathalie Rolhion, Harry Sokol

Nat Rev Gastroenterol Hepatol. 2021 Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases associated with gut microbiota alterations. FMT cures 90% of...
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