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March 17 - 2020

Activation of innate immunity by 14-3-3 epsilon, a new potential alarmin in osteoarthritis (Équipe Berenbaum) M. Millerand, L. Sudre, M. Nefla, F. Pène, C. Rousseau, A. Pons, A. Ravat, G. André-Leroux, S. Akira, T. Satoh, F. Berenbaum, C. Jacques

Osteoarthritis Cartilage. 2020;28(5):646-57 OBJECTIVE : The innate immune system plays a central role in osteoarthritis (OA). We identified 14-3-3epsilon as a novel mediator that guides...

May 01 - 2020

Atypical presentation of COVID-19 in young infants (Équipe Corvol) Nadia Nathan, Blandine Prévost, Harriet Corvol

Lancet. 2020;395(10235):1481 As of April 27, 2020, more than two million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), with Europe being one of the current...

August 20 - 2020

Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells (Équipe Corvol) Manon Ruffin, Jeanne Bigot, Claire Calmel, Harriet Corvol, Viviane Balloy, Loïc Guillot

BioRxiv The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce...

June 24 - 2020

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? (Équipe Corvol) Jean-Michel Sallenave, Loïc Guillot

Front Immunol. 2020;11:1229 COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome....

July 31 - 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19 (Équipe Dorothée) Mireille Laforge, Carole Elbim, Corinne Frere, Miryana Hemadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker

Nat Rev Immunol. 2020;20(9):515-6 The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species...

April 28 - 2020

Photothermal Depletion of Cancer-Associated Fibroblasts Normalizes Tumor Stiffness in Desmoplastic Cholangiocarcinoma (Équipe Housset) Alba Nicolás-Boluda, Javier Vaquero, Gautier Laurent, Gilles Renault, Rana Bazzi, Emmanuel Donnadieu, Stéphane Roux, Laura Fouassier, Florence Gazeau

ACS Nano. 2020;14(5):5738-53 Physical oncology recognizes tissue stiffness mediated by activation of cancer-associated fibroblasts (CAF) and extracellular matrix remodeling as an active...

December 11 - 2020

Introduction to host microbiome symbiosis in health and disease (Équipe Mohty) Florent Malard, Joel Dore, Beatrice Gaugler, Mohamad Mohty

Mucosal Immunol. 2020 Humans share a core intestinal microbiome and yet human microbiome differs by genes, species, enterotypes (ecology), and gene count (microbial diversity). Achievement...

June 04 - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty) Yishan Ye, Béatrice Gaugler, Mohamad Mohty, Florent Malard

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...

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