Physiol Rep. 2018;6(8):e13678
The RORalpha-deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased not only in...
Int J Cancer. 2018;143(10):2458-69
Insulin and insulin-like growth factor (IGF)-1 signaling in the thyroid are thought to be permissive for the coordinated regulation by thyroid-stimulating...
N Engl J Med. 2018;378(23):2171-81
Background : Patients with primary biliary cholangitis who have an inadequate response to therapy with ursodeoxycholic acid are at high risk for disease...
Hepatol Commun. 2018;2(12):1533-49
The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the...
Biophys Acta Mol Basis Dis. 2018;1864(12):3688-96
Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal...
Aliment Pharmacol Ther. 2019;49(3):308-20
Background : No blood test has been shown to be effective in the prediction of primary liver cancer in patients without cirrhosis. AIM: To...
Clin Cancer Res. 2018;24(17):4282-96
Purpose : Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and...
Genet Med. 2018;20(2):250-8
Purpose : Fetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many...
Nat Rev Endocrinol. 2018;14(4):229-49
Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...
Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34
Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...
Med Genet. 2018;55(3):205-13
Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...
Lab Invest. 2018;98(2):164-74
Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...
Dev Cell. 2018;45(6):712-25 e6
Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
Lab Invest. 2018;98(6):696-707
Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
Stem Cells. 2018;36(9):1421-9
Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
Cancer Res. 2018;78(3):659-70
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
Hepatology. 2018;68(4):1534-48
Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
Nat Commun. 2018;9(1):1216
Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
