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August 10 - 2017

Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction (Équipe Netchine) Walid Abi Habib, Frédéric Brioude, Thomas Edouard, James T. Bennett, Anne Lienhardt-Roussie, Frédérique Tixier, Jennifer Salem, Tony Yuen, Salah Azzi, Yves Le Bouc, Madeleine D. Harbison, Irène Netchine

Genet Med. 2018;20(2):250-8 Purpose : Fetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many...
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COUVERT Philippe

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January 29 - 2018

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement. (Équipe Netchine) F. Brioude, J.M. Kalish, A.Mussa, A.C. Foster, J. Bliek, G. Battista Ferrero, S.E. Boonen, T. Cole, R. Baker, M. Bertoletti, G. Cocchi, C. Coze, M. De Pellegrin, K. Hussain, A. Ibrahim, M.D. Kilby, M. Krajewska-Walasek, C.P. Kratz, E.J. Ladusans, P.Lapunzina, Y.Le Bouc, S.M. Maas, F.Macdonald, K.Õunap, L.Peruzzi, S.Rossignol, S.Russo, C.Shipster, A.Skórka, K. Tatton-Brown, J. Tenorio, C. Tortora, K. Grønskov, I. Netchine, R. C. Hennekam, D. Prawitt, Z. Tümer, T. Eggermann, D.J.G. Mackay, A. Ricc

Nat Rev Endocrinol. 2018;14(4):229-49 Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...
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April 11 - 2018

Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome (Équipe Netchine) S. Geoffron, W. Abi Habib, S. Chantot-Bastaraud, B. Dubern, V. Steunou, S. Azzi, A. Afenjar, T. Busa, A. Pinheiro Canton, C. Chalouhi, M.-N. Dufourg, B. Esteva, M. Fradin, D. Geneviève, S. Heide, B. Isidor, A. Linglart, F. Morice Picard, C. Naud-Saudreau, I. Oliver Petit, N. Philip, C. Pienkowski, M. Rio, S. Rossignol, M. Tauber, J. Thevenon, T.A. Vu-Hong, M.D. Harbison, J. Salem, F. Brioude, I. Netchine, E. Giabicani

J Clin Endocrinol Metab. 2018;103(7):2436-46 Context : Silver-Russell syndrome (SRS) (mainly secondary to 11p15 molecular disruption) and Temple syndrome (TS) (secondary to 14q32.2...
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CREUSOT Laura

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August 01 - 2018

Diagnosis and management of postnatal fetal growth restriction (Équipe Netchine) Eloïse Giabicani, Aurélie Pham, Frédéric Brioude, Delphine Mitanchez, Irène Netchine

Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34 Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...
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December 09 - 2017

Chromosomal rearrangements in the 11p15 imprinted region: 17 new 11p15.5 duplications with associated phenotypes and putative functional consequences (Équipe Netchine) Solveig Heide, Sandra Chantot-Bastaraud, Boris Keren, Madeleine D Harbison, Salah Azzi, Sylvie Rossignol, Caroline Michot, Marilyn Lackmy-Port Lys, Bénédicte Demeer, Claudine Heinrichs, Ron S Newfield, Pierre Sarda, Lionel Van Maldergem, Véronique Trifard, Eloise Giabicani, Jean-Pierre Siffroi, Yves Le Bouc, Irène Netchine, Frédéric Brioude

Med Genet. 2018;55(3):205-13 Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...
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DA SILVA LIMA Francieton

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February 16 - 2018

The NDPK/NME superfamily: state of the art (Équipe Prunier) Mathieu Boissan, Uwe Schlattner, Marie-Lise Lacombe

Lab Invest. 2018;98(2):164-74 Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...
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June 18 - 2018

Twist1 activation in muscle progenitor cells causes muscle loss akin to cancer cachexia (Équipe Prunier) Parash Parajuli, Santosh Kumar, Audrey Loumaye, Purba Singh, Sailaja Eragamreddy, Thien Ly Nguyen, Seval Ozkan, Mohammed S. Razzaque, Céline Prunier, Jean-Paul Thissen, Azeddine Atfi

Dev Cell. 2018;45(6):712-25 e6 Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
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DALISSIER Arnaud

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March 01 - 2018

The extracellular domain of Her2 in serum as a biomarker of breast cancer (Équipe Prunier) Alexandre Perrier, Joseph Gligorov, Guillaume Lefèvre, Mathieu Boissan

Lab Invest. 2018;98(6):696-707 Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
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DANNE Camille

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May 29 - 2018

Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein (Équipe Prunier) Lauriane N. Roux, Isabelle Petit, Romain Domart, Jean-Paul Concordet, Jieqiong Qu, Huiqing Zhou, Alain Joliot, Olivier Ferrigno, Daniel Aberdam

Stem Cells. 2018;36(9):1421-9 Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
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February 01 - 2018

Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation (Équipe Prunier) Joke Tommelein, Elly De Vlieghere, Laurine Verset, Élodie Melsens, Justine Leenders, Bénédicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P.Gespach, Anne Vral, De Astrid Boeck, Karin Haustermans, de Pascal Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever

Cancer Res. 2018;78(3):659-70 Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
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DARWANE Nadia

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April 10 - 2018

Influence of Progenitor-Derived Regeneration Markers on Hepatitis C Virus-Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort) (Équipe Prunier) Dominique Wendum, Richard Layese, Nathalie Ganne-Carrie, Valérie Bourcier, Fatiha Merabtene, Carole Cagnot, Emmanuel Sauce, Nathalie Barget, Pierre Bedossa, Benoît Terris, Janick Selves, Paulette Bioulac-Sage, Nathalie Sturm, Christophe Sattonnet, Pierre Nahon, Françoise Roudot-Thoraval, Marianne Ziol

Hepatology. 2018;68(4):1534-48 Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
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DE OLIVEIRA FORMIGA Rodrigo

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March 23 - 2018

The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development (Équipe Prunier) Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journe, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers

Nat Commun. 2018;9(1):1216 Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
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DE SORDI Luisa

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June 13 - 2018

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease (Équipe Seksik/Sokol) Allison Agus, Julien Planchais, Harry Sokol

Cell Host Microbe. 2018;23(6):716-24 The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
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November 01 - 2018

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Équipe Seksik/Sokol) Dragos Ciocan, Cosmin Sebastian Voican, Laura Wrzosek, Cindy Hugot, Dominique Rainteau, Lydie Humbert, Anne-Marie Cassard, Gabriel Perlemuter

Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...
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October 22 - 2018

Mixed signals from the cell's antennae: primary cilia in cancer (Équipe Seksik/Sokol) Thibaut Eguether, Michael Hahne

EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
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DE VASSOIGNE Frédéric

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May 15 - 2018

Intraflagellar transport is deeply integrated in hedgehog signaling (Équipe Seksik/Sokol) Thibaut Eguether, Fabrice P. Cordelieres, Gregory J. Pazoura

Mol Biol Cell. 2018;29(10):1178-89 The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...
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July 09 - 2018

Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes (Équipe Seksik/Sokol) Laurent Genser, Doriane Aguanno, Hédi A. Soula, Liping Dong, Laurence Trystram, Karen Assmann, Joe‐Elie Salem, Jean‐Christophe Vaillant, Jean‐Michel Oppert, Fabienne Laugerette, Marie‐Caroline Michalski, Philippe Wind, Monique Rousset, Edith Brot‐Laroche, Armelle Leturque, Karine Clément, Sophie Thenet, Christine Poitou

J Pathol. 2018;246(2):217-30 Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...
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DEBOST Henry

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September 11 - 2018

Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Équipe Seksik/Sokol) Lydie Humbert, Dominique Rainteau, Noshine Tuvignon, Claude Wolf, Philippe Seksik, René Laugier, Frédéric Carriere

J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
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DECOBERT Alix

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October 01 - 2018

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence (Équipe Seksik/Sokol) Bruno Lamas, Marie-Laure Michel, Nadine Waldschmitt, Hang-Phuong Pham, Vassiliki Zacharioudaki, Louise Dupraz, Myriam Delacre, Jane M. Natividad, Gregory Da Costa, Julien Planchais, Bruno Sovran, Chantal Bridonneau, Adrien Six, Philippe Langella, Mathias L. Richard, Mathias Chamaillard, Harry Sokol

Gut. 2018;67(10):1836-44 Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
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St. Antoine Hospital

INSERM
Kourilsky Building
34 rue Crozatier - 75012 Paris
France

Sorbonne Université Medicine
Saint-Antoine Site
27 rue Chaligny - 75012 Paris
France

+(33)1 49 28 46 00
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