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August 01 - 2018

Diagnosis and management of postnatal fetal growth restriction (Équipe Netchine) Eloïse Giabicani, Aurélie Pham, Frédéric Brioude, Delphine Mitanchez, Irène Netchine

Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34 Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...

February 16 - 2018

The NDPK/NME superfamily: state of the art (Équipe Prunier) Mathieu Boissan, Uwe Schlattner, Marie-Lise Lacombe

Lab Invest. 2018;98(2):164-74 Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...

June 18 - 2018

Twist1 activation in muscle progenitor cells causes muscle loss akin to cancer cachexia (Équipe Prunier) Parash Parajuli, Santosh Kumar, Audrey Loumaye, Purba Singh, Sailaja Eragamreddy, Thien Ly Nguyen, Seval Ozkan, Mohammed S. Razzaque, Céline Prunier, Jean-Paul Thissen, Azeddine Atfi

Dev Cell. 2018;45(6):712-25 e6 Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...

March 01 - 2018

The extracellular domain of Her2 in serum as a biomarker of breast cancer (Équipe Prunier) Alexandre Perrier, Joseph Gligorov, Guillaume Lefèvre, Mathieu Boissan

Lab Invest. 2018;98(6):696-707 Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...

June 13 - 2018

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease (Équipe Seksik/Sokol) Allison Agus, Julien Planchais, Harry Sokol

Cell Host Microbe. 2018;23(6):716-24 The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...

November 01 - 2018

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Équipe Seksik/Sokol) Dragos Ciocan, Cosmin Sebastian Voican, Laura Wrzosek, Cindy Hugot, Dominique Rainteau, Lydie Humbert, Anne-Marie Cassard, Gabriel Perlemuter

Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...

October 22 - 2018

Mixed signals from the cell's antennae: primary cilia in cancer (Équipe Seksik/Sokol) Thibaut Eguether, Michael Hahne

EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...

May 15 - 2018

Intraflagellar transport is deeply integrated in hedgehog signaling (Équipe Seksik/Sokol) Thibaut Eguether, Fabrice P. Cordelieres, Gregory J. Pazoura

Mol Biol Cell. 2018;29(10):1178-89 The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...

September 11 - 2018

Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Équipe Seksik/Sokol) Lydie Humbert, Dominique Rainteau, Noshine Tuvignon, Claude Wolf, Philippe Seksik, René Laugier, Frédéric Carriere

J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...

April 07 - 2018

Aryl hydrocarbon receptor and intestinal immunity (Équipe Seksik/Sokol) Bruno Lamas, Jane M. Natividad, Harry Sokol

Mucosal Immunol. 2018;11(4):1024-38 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...
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