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July 09 - 2018

Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes (Équipe Seksik/Sokol) Laurent Genser, Doriane Aguanno, Hédi A. Soula, Liping Dong, Laurence Trystram, Karen Assmann, Joe‐Elie Salem, Jean‐Christophe Vaillant, Jean‐Michel Oppert, Fabienne Laugerette, Marie‐Caroline Michalski, Philippe Wind, Monique Rousset, Edith Brot‐Laroche, Armelle Leturque, Karine Clément, Sophie Thenet, Christine Poitou

J Pathol. 2018;246(2):217-30 Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...

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DELAUNAY Jean-Louis

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September 11 - 2018

Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Équipe Seksik/Sokol) Lydie Humbert, Dominique Rainteau, Noshine Tuvignon, Claude Wolf, Philippe Seksik, René Laugier, Frédéric Carriere

J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...

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October 01 - 2018

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence (Équipe Seksik/Sokol) Bruno Lamas, Marie-Laure Michel, Nadine Waldschmitt, Hang-Phuong Pham, Vassiliki Zacharioudaki, Louise Dupraz, Myriam Delacre, Jane M. Natividad, Gregory Da Costa, Julien Planchais, Bruno Sovran, Chantal Bridonneau, Adrien Six, Philippe Langella, Mathias L. Richard, Mathias Chamaillard, Harry Sokol

Gut. 2018;67(10):1836-44 Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...

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DELHOMMEAU François

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April 07 - 2018

Aryl hydrocarbon receptor and intestinal immunity (Équipe Seksik/Sokol) Bruno Lamas, Jane M. Natividad, Harry Sokol

Mucosal Immunol. 2018;11(4):1024-38 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...

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DELOBELLE Quentin

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August 29 - 2018

Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota (Équipe Seksik/Sokol) Cécilia Landman, Jean-Pierre Grill, Jean-Maurice Mallet, Philippe Marteau, Lydie Humbert, Eric Le Balc’h, Marie-Anne Maubert, Kevin Perez, Wahiba Chaara, Loic Brot, Laurent Beaugerie, Harry Sokol, Sophie Thenet, Dominique Rainteau, Philippe Seksik, Elodie Quévrain, Conceptualization, Funding acquisition, The Saint Antoine IBD Network

PLoS One. 2018;13(8):e0202587 Background and Aims : N-acyl homoserine lactones (AHLs), which are autoinducer quorum-sensing molecules involved in the bacterial communication network, also...

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February 01 - 2018

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells (Équipe Seksik/Sokol) Etienne Morel, Sara Ghezzal, Géraldine Lucchi, Caroline Truntzer, Jean-Paul Pais de Barros, Françoise Simon-Plas, Sylvie Demignot, Chieko Mineo, Philip W. Shaul, Armelle Leturque, Monique Rousset, Véronique Carrière

Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(2):199-211 Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent...

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November 06 - 2018

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome (Équipe Seksik/Sokol) Jane M. Natividad, Allison Agus, Julien Planchais, Bruno Lamas, Anne Charlotte Jarry, Rebeca Martin, Marie-Laure Michel, Caroline Chong-Nguyen, Ronan Roussel, Marjolene Straube, Sarah Jegou, Claire McQuitty, Maude Le Gall, Gregory da Costa, Emmanuelle Lecornet, Chloé Michaudel, Morgane Modoux, Jeremy Glodt, Chantal Bridonneau, Bruno Sovran, Louise Dupraz, Andre Bado, Mathias L. Richard, Philippe Langella, Boris Hansel, Jean-Marie Launay, Ramnik J. Xavier, Henri Duboc, Harry Sokol

Cell Metab. 2018;28(5):737-49 e4 The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota...

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DEMIGNOT Sylvie

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DENAMUR Sophie

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July 18 - 2018

Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice (Équipe SeksikSokol) Jane M. Natividad, Bruno Lamas, Hang Phuong Pham, Marie-Laure Michel, Dominique Rainteau, Chantal Bridonneau, Gregory da Costa, Johan van Hylckama Vlieg, Bruno Sovran, Celia Chamignon, Julien Planchais, Mathias L. Richard, Philippe Langella, Patrick Veiga, Harry Sokol

Nat Commun. 2018;9(1):2802 Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly...

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DENIS Jérôme

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March 04 - 2018

Mucosa-associated microbiota dysbiosis in colitis associated cancer (Équipe Seksik/Sokol) Mathias L. Richard, Giuseppina Liguori, Bruno Lamas, Giovanni Brandi, Gregory da Costa, Thomas W. Hoffmann, Massimo Pierluigi Di Simone, Carlo Calabrese, Gilberto Poggioli, Philippe Langella, Massimo Campieri, Harry Sokol

Gut Microbes. 2018;9(2):131-42 Gut microbiota dysbiosis has been associated with inflammatory bowel diseases (IBD). In colorectal cancer, the gut microbiota has also been recognized as...

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March 01 - 2018

Glycerolipid analysis during desiccation and recovery of the resurrection plant Xerophyta humilis (Bak) Dur and Schinz (Équipe Seksik/Sokol) Freedom Tshabuse, Jill M. Farrant, Lydie Humbert, Deborah Moura, Dominique Rainteau, Christophe Espinasse, Abdelghani Idrissi, Franck Merlier, Sébastien Acket, Mohamad S. Rafudeen, Brigitte Thomasset, Eric Ruelland

Plant Cell Environ. 2018;41(3):533-47 Xerophyta humilis is a poikilochlorophyllous monocot resurrection plant used as a model to study vegetative desiccation tolerance. Dehydration imposes...

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