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June 18 - 2018

Twist1 activation in muscle progenitor cells causes muscle loss akin to cancer cachexia (Équipe Prunier) Parash Parajuli, Santosh Kumar, Audrey Loumaye, Purba Singh, Sailaja Eragamreddy, Thien Ly Nguyen, Seval Ozkan, Mohammed S. Razzaque, Céline Prunier, Jean-Paul Thissen, Azeddine Atfi

Dev Cell. 2018;45(6):712-25 e6 Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
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March 01 - 2018

The extracellular domain of Her2 in serum as a biomarker of breast cancer (Équipe Prunier) Alexandre Perrier, Joseph Gligorov, Guillaume Lefèvre, Mathieu Boissan

Lab Invest. 2018;98(6):696-707 Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
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DELAUNAY Jean-Louis

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May 29 - 2018

Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein (Équipe Prunier) Lauriane N. Roux, Isabelle Petit, Romain Domart, Jean-Paul Concordet, Jieqiong Qu, Huiqing Zhou, Alain Joliot, Olivier Ferrigno, Daniel Aberdam

Stem Cells. 2018;36(9):1421-9 Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
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February 01 - 2018

Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation (Équipe Prunier) Joke Tommelein, Elly De Vlieghere, Laurine Verset, Élodie Melsens, Justine Leenders, Bénédicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P.Gespach, Anne Vral, De Astrid Boeck, Karin Haustermans, de Pascal Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever

Cancer Res. 2018;78(3):659-70 Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
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DELHOMMEAU François

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April 10 - 2018

Influence of Progenitor-Derived Regeneration Markers on Hepatitis C Virus-Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort) (Équipe Prunier) Dominique Wendum, Richard Layese, Nathalie Ganne-Carrie, Valérie Bourcier, Fatiha Merabtene, Carole Cagnot, Emmanuel Sauce, Nathalie Barget, Pierre Bedossa, Benoît Terris, Janick Selves, Paulette Bioulac-Sage, Nathalie Sturm, Christophe Sattonnet, Pierre Nahon, Françoise Roudot-Thoraval, Marianne Ziol

Hepatology. 2018;68(4):1534-48 Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
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DELOBELLE Quentin

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March 23 - 2018

The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development (Équipe Prunier) Stefanie Wojciech, Raise Ahmad, Zakia Belaid-Choucair, Anne-Sophie Journe, Sarah Gallet, Julie Dam, Avais Daulat, Delphine Ndiaye-Lobry, Olivier Lahuna, Angeliki Karamitri, Jean-Luc Guillaume, Marcio Do Cruzeiro, François Guillonneau, Anastasia Saade, Nathalie Clément, Thomas Courivaud, Nawel Kaabi, Kenjiro Tadagaki, Philippe Delagrange, Vincent Prévot, Olivier Hermine, Céline Prunier, Ralf Jockers

Nat Commun. 2018;9(1):1216 Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
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June 13 - 2018

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease (Équipe Seksik/Sokol) Allison Agus, Julien Planchais, Harry Sokol

Cell Host Microbe. 2018;23(6):716-24 The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
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November 01 - 2018

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Équipe Seksik/Sokol) Dragos Ciocan, Cosmin Sebastian Voican, Laura Wrzosek, Cindy Hugot, Dominique Rainteau, Lydie Humbert, Anne-Marie Cassard, Gabriel Perlemuter

Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...
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DEMIGNOT Sylvie

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DENAMUR Sophie

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October 22 - 2018

Mixed signals from the cell's antennae: primary cilia in cancer (Équipe Seksik/Sokol) Thibaut Eguether, Michael Hahne

EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
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DENIS Jérôme

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May 15 - 2018

Intraflagellar transport is deeply integrated in hedgehog signaling (Équipe Seksik/Sokol) Thibaut Eguether, Fabrice P. Cordelieres, Gregory J. Pazoura

Mol Biol Cell. 2018;29(10):1178-89 The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...
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July 09 - 2018

Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes (Équipe Seksik/Sokol) Laurent Genser, Doriane Aguanno, Hédi A. Soula, Liping Dong, Laurence Trystram, Karen Assmann, Joe‐Elie Salem, Jean‐Christophe Vaillant, Jean‐Michel Oppert, Fabienne Laugerette, Marie‐Caroline Michalski, Philippe Wind, Monique Rousset, Edith Brot‐Laroche, Armelle Leturque, Karine Clément, Sophie Thenet, Christine Poitou

J Pathol. 2018;246(2):217-30 Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...
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September 11 - 2018

Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Équipe Seksik/Sokol) Lydie Humbert, Dominique Rainteau, Noshine Tuvignon, Claude Wolf, Philippe Seksik, René Laugier, Frédéric Carriere

J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
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DESMONS Aurore

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October 01 - 2018

Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence (Équipe Seksik/Sokol) Bruno Lamas, Marie-Laure Michel, Nadine Waldschmitt, Hang-Phuong Pham, Vassiliki Zacharioudaki, Louise Dupraz, Myriam Delacre, Jane M. Natividad, Gregory Da Costa, Julien Planchais, Bruno Sovran, Chantal Bridonneau, Adrien Six, Philippe Langella, Mathias L. Richard, Mathias Chamaillard, Harry Sokol

Gut. 2018;67(10):1836-44 Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
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DESPRAS Emmanuelle

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April 07 - 2018

Aryl hydrocarbon receptor and intestinal immunity (Équipe Seksik/Sokol) Bruno Lamas, Jane M. Natividad, Harry Sokol

Mucosal Immunol. 2018;11(4):1024-38 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...
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DESPRÉS Gaëtan

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August 29 - 2018

Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota (Équipe Seksik/Sokol) Cécilia Landman, Jean-Pierre Grill, Jean-Maurice Mallet, Philippe Marteau, Lydie Humbert, Eric Le Balc’h, Marie-Anne Maubert, Kevin Perez, Wahiba Chaara, Loic Brot, Laurent Beaugerie, Harry Sokol, Sophie Thenet, Dominique Rainteau, Philippe Seksik, Elodie Quévrain, Conceptualization, Funding acquisition, The Saint Antoine IBD Network

PLoS One. 2018;13(8):e0202587 Background and Aims : N-acyl homoserine lactones (AHLs), which are autoinducer quorum-sensing molecules involved in the bacterial communication network, also...
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February 01 - 2018

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells (Équipe Seksik/Sokol) Etienne Morel, Sara Ghezzal, Géraldine Lucchi, Caroline Truntzer, Jean-Paul Pais de Barros, Françoise Simon-Plas, Sylvie Demignot, Chieko Mineo, Philip W. Shaul, Armelle Leturque, Monique Rousset, Véronique Carrière

Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(2):199-211 Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent...
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DI CLEMENTE RENAULD-BESSE Nathalie

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November 06 - 2018

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome (Équipe Seksik/Sokol) Jane M. Natividad, Allison Agus, Julien Planchais, Bruno Lamas, Anne Charlotte Jarry, Rebeca Martin, Marie-Laure Michel, Caroline Chong-Nguyen, Ronan Roussel, Marjolene Straube, Sarah Jegou, Claire McQuitty, Maude Le Gall, Gregory da Costa, Emmanuelle Lecornet, Chloé Michaudel, Morgane Modoux, Jeremy Glodt, Chantal Bridonneau, Bruno Sovran, Louise Dupraz, Andre Bado, Mathias L. Richard, Philippe Langella, Boris Hansel, Jean-Marie Launay, Ramnik J. Xavier, Henri Duboc, Harry Sokol

Cell Metab. 2018;28(5):737-49 e4 The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota...
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July 18 - 2018

Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice (Équipe SeksikSokol) Jane M. Natividad, Bruno Lamas, Hang Phuong Pham, Marie-Laure Michel, Dominique Rainteau, Chantal Bridonneau, Gregory da Costa, Johan van Hylckama Vlieg, Bruno Sovran, Celia Chamignon, Julien Planchais, Mathias L. Richard, Philippe Langella, Patrick Veiga, Harry Sokol

Nat Commun. 2018;9(1):2802 Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly...
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DIEHL Aurélien

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March 04 - 2018

Mucosa-associated microbiota dysbiosis in colitis associated cancer (Équipe Seksik/Sokol) Mathias L. Richard, Giuseppina Liguori, Bruno Lamas, Giovanni Brandi, Gregory da Costa, Thomas W. Hoffmann, Massimo Pierluigi Di Simone, Carlo Calabrese, Gilberto Poggioli, Philippe Langella, Massimo Campieri, Harry Sokol

Gut Microbes. 2018;9(2):131-42 Gut microbiota dysbiosis has been associated with inflammatory bowel diseases (IBD). In colorectal cancer, the gut microbiota has also been recognized as...
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St. Antoine Hospital

INSERM
Kourilsky Building
34 rue Crozatier - 75012 Paris
France

Sorbonne Université Medicine
Saint-Antoine Site
27 rue Chaligny - 75012 Paris
France

+(33)1 49 28 46 00
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