Latest publications

Publication of various scientific studies

December 11 - 2020

The differentiation of prehypertrophic into hypertrophic chondrocytes drives an OA-remodeling program and IL-34 expression (Équipe Berenbaum)

Osteoarthritis Cartilage 29 (2021): 257-268 OBJECTIVES : We hypothesize that chondrocytes from the deepest articular cartilage layer are pivotal in maintaining cartilage integrity and that...

December 05 - 2020

Gut microbiota-derived metabolites as central regulators in metabolic disorders (Équipe Seksik - Sokol)

Gut. 2020 Metabolic disorders represent a growing worldwide health challenge due to their dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact with...

December 02 - 2020

Tryptophan Metabolism as a Pharmacological Target (Équipe Seksik - Sokol)

Trends Pharmacol Sci. 2020 L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many...

November 14 - 2020

Role of adipose tissues in osteoarthritis (Équipe Berenbaum)

Curr Opin Rheumatol 33 (2021): 84-93 PURPOSE OF REVIEW : Epidemiologic studies reveal that the link between obesity and osteoarthritis cannot be uniquely explained by overweight-associated...

October 27 - 2020

The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption (Équipe Seksik - Sokol)

Tissue Barriers. 2020;8(4):1832877 The intestine is home to the largest microbiota community of the human body and strictly regulates its barrier function. Tight junctions (TJ) are major...

October 23 - 2020

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation (Équipe Seksik - Sokol)

Sci Transl Med. 2020;12(566) Metabolism of tryptophan by the gut microbiota into derivatives that activate the aryl hydrocarbon receptor (AhR) contributes to intestinal homeostasis. Many...

October 03 - 2020

High-dose post-transplant cyclophosphamide impairs gammadelta T-cell reconstitution after haploidentical haematopoietic stem cell transplantation using low-dose antithymocyte globulin and peripheral blood stem cell graft (Équipe Mohty)

Clin Transl Immunology. 2020;9(9):e1171 OBJECTIVES : Haploidentical haematopoietic cell transplantation (Haplo-HCT) using peripheral blood stem cell (PBSC) grafts and post-transplant...

September 29 - 2020

Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity (Équipe Seksik - Sokol)

Front Immunol. 2020;11:1827 Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the...

September 23 - 2020

Derivation and Validation of a Predictive Score for Disease Worsening in Patients with COVID-19 (Équipe Larsen-Sabbah)

Thromb Haemost. 2020 The prospective observational cohort study COMPASS-COVID-19 aimed to develop a risk assessment model for early identification of hospitalized COVID-19 patients at risk...

September 22 - 2020

Changes in circulating miRNA19a-3p precede insulin resistance programmed by intra-uterine growth retardation in mice (Équipe Netchine / Fève / Seksik - Sokol)

Mol Metab. 2020;42:101083 OBJECTIVE : Individuals born with intrauterine growth retardation (IUGR) are more prone to cardio-metabolic diseases as adults, and environmental changes during...
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France

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