Latest publications

Publication of various scientific studies

June 09 - 2022

3-oxo-C12:2-HSL, quorum sensing molecule from human intestinal microbiota, inhibits pro-inflammatory pathways in immune cells via bitter taste receptors (Équipe Seksik-Sokol)

Sci Rep 2022; 12: 9440 In the gut ecosystem, microorganisms regulate group behaviour and interplay with the host via a molecular system called quorum sensing (QS). The QS molecule...
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June 09 - 2022

Deciphering pathological remodelling of the human cartilage extracellular matrix in osteoarthritis at the supramolecular level (Équipe Berenbaum)

Nanoscale 2022; 14: 8691-8708 The extracellular matrix (ECM) of articular cartilage is a three-dimensional network mainly constituted of entangled collagen fibrils and interfibrillar...
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June 02 - 2022

Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice (Équipe Duval)

Cell Mol Life Sci 2022; 79: 332 Heat shock proteins (HSPs) play oncogenic roles in human tumours. We reported a somatic inactivating mutation of HSP110 (HSP110DE9) in mismatch...
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June 01 - 2022

Fecal microbiota and bile acids in IBD patients undergoing screening for colorectal cancer (Équipe Seksik/Sokol)

Gut Microbes 2022; 14: 2078620 Due to the potential role of the gut microbiota and bile acids in the pathogenesis of both inflammatory bowel disease (IBD) and sporadic colorectal cancer, we...
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May 28 - 2022

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes (Équipe Gautheron/Housset / Fève)

BMC Med. 2022 Mar 28;20(1):95 BACKGROUND : Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the...
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May 18 - 2022

(99m)Tc-NTP 15-5 is a companion radiotracer for assessing joint functional response to sprifermin (rhFGF-18) in a murine osteoarthritis model (Équipe Berenbaum)

Sci Rep 2022; 12: 8146 With the emergence of disease modifying osteoarthritis drugs (DMOAD), imaging methods to quantitatively demonstrate their efficacy and to monitor osteoarthritis...
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May 11 - 2022

Human CD4+/CD8alpha+ regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation (Équipe Seksik-Sokol)

JCI Insight 2022 Faecalibacterium prausnitzii (F. prausnitzii), a dominant bacterium of the human microbiota, is decreased in patients with inflammatory bowel diseases (IBD) and exhibits...
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April 29 - 2022

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis (Équipe Berenbaum)

Front Immunol 2022; 13: 842538 Introduction : Osteoarthritis (OA) is a whole-joint disease characterized by a low-grade inflammation that is involved in both cartilage degradation and...
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April 02 - 2022

Dental pulp stem cells as a promising model to study imprinting diseases (Équipe Netchine)

  PInt J Oral Sci 2022; 14: 19 arental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental origin. Imprinting diseases are...
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March 15 - 2022

Targeting the GLP-1/GLP-1R axis to treat osteoarthritis: A new opportunity? (Équipe Berenbaum)

J Orthop Translat 2022; 32: 121-129 Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In OA, chondrocytes, synovial cells and other joint cells...
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France

Sorbonne Université Medicine
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France

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