Latest publications

Publication of various scientific studies

June 01 - 2023

Prediction of response to immune checkpoint blockade in patients with metastatic colorectal cancer with microsatellite instability (Team Duval)

Ann Oncol. 2023 Aug;34(8):703-713 BACKGROUND : Mismatch repair-deficient (dMMR) tumors displaying microsatellite instability (MSI) represent a paradigm for the success of immune...
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January 08 - 2023

Ivacaftor-Mediated Potentiation of ABCB4 Missense Mutations Affecting Critical Motifs of the NBDs: Repositioning Perspectives for Hepatobiliary Diseases (Équipe Gautheron/Housset)

Int J Mol Sci. 2023 Jan 8;24(2):1236 ABCB4 (ATP-binding cassette subfamily B member 4) is a hepatocanalicular floppase involved in biliary phosphatidylcholine (PC) secretion. Variations in...
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December 29 - 2022

Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells (Équipe Netchine)

Clin Epigenetics 2022; 14: 190. BACKGROUND : Parental imprinting is an epigenetic mechanism that leads to monoallelic expression of a subset of genes depending on their parental origin....
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December 06 - 2022

Interference with Lipoprotein Maturation Sensitizes Methicillin-Resistant Staphylococcus aureus to Human Group IIA-Secreted Phospholipase A2 and Daptomycin (Équipe Corvol)

J Innate Immun. 2022 Dec 6:1-18 Methicillin-resistant Staphylococcus aureus (MRSA) has been classified as a high priority pathogen by the World Health Organization underlining the high...
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December 01 - 2022

Diversity of the nucleic acid forms of circulating HBV in chronically infected patients and its impact on viral cycle (Équipe Gautheron/Housset)

Hepatol Int 2022 Vol. 16 Issue 6 Pages 1259-1272 BACKGROUND : Besides the prototypical hepatitis B virus (HBV) infectious particle, which contains a full-length double-stranded DNA...
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December 01 - 2022

Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis (Équipe Gautheron/Housset)

J Hepatol 2022 Vol. 77 Issue 6 Pages 1545-1553 BACKGROUND & AIMS : Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) has been shown to predict...
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November 30 - 2022

Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens (Équipe Corvol)

J Fungi (Basel). 2022 Nov 30;8(12):1268 Bronchial epithelial cells (BEC) play a crucial role in innate immunity against inhaled fungi. Indeed, in response to microorganisms, BEC synthesize...
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November 01 - 2022

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis (Équipe Gautheron/Housset)

Hepatology 2022 BACKGROUND & AIMS : In liver fibrosis, myofibroblasts derive from hepatic stellate cells (HSCs) and as yet undefined mesenchymal cells. We aimed to identify portal...
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October 21 - 2022

The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes (Équipe Gautheron/Housset / Fève)

iScience, Volume 25, ISSUE 10, 105166, October 21, 2022 Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain- like (MLKL) proteins are key regulators of...
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September 27 - 2022

CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival (Équipe XXXX)

Gut. 2022 OBJECTIVES : Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to...
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France

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France

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