Nat Rev Endocrinol. 2018;14(4):229-49
Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...
Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34
Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...
Med Genet. 2018;55(3):205-13
Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...
Lab Invest. 2018;98(2):164-74
Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...
Dev Cell. 2018;45(6):712-25 e6
Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
Lab Invest. 2018;98(6):696-707
Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
Stem Cells. 2018;36(9):1421-9
Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
Cancer Res. 2018;78(3):659-70
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
Hepatology. 2018;68(4):1534-48
Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
Nat Commun. 2018;9(1):1216
Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
Cell Host Microbe. 2018;23(6):716-24
The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
Aliment Pharmacol Ther. 2018;48(9):961-74
Background : Intestinal microbiota plays an important role in bile acid homeostasis.
Aim : To study the structure of the intestinal microbiota...
EMBO Rep. 2018;19(11)
Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
Mol Biol Cell. 2018;29(10):1178-89
The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...
J Pathol. 2018;246(2):217-30
Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...
J Lipid Res. 2018;59(11):2202-13
Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
Gut. 2018;67(10):1836-44
Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
Mucosal Immunol. 2018;11(4):1024-38
Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...
