Dev Cell. 2018;45(6):712-25 e6
Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
Lab Invest. 2018;98(6):696-707
Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
Stem Cells. 2018;36(9):1421-9
Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
Cancer Res. 2018;78(3):659-70
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
Hepatology. 2018;68(4):1534-48
Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
Nat Commun. 2018;9(1):1216
Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
Cell Host Microbe. 2018;23(6):716-24
The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
Aliment Pharmacol Ther. 2018;48(9):961-74
Background : Intestinal microbiota plays an important role in bile acid homeostasis.
Aim : To study the structure of the intestinal microbiota...
EMBO Rep. 2018;19(11)
Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
Mol Biol Cell. 2018;29(10):1178-89
The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...
J Pathol. 2018;246(2):217-30
Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...
J Lipid Res. 2018;59(11):2202-13
Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
Gut. 2018;67(10):1836-44
Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
Mucosal Immunol. 2018;11(4):1024-38
Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...
PLoS One. 2018;13(8):e0202587
Background and Aims : N-acyl homoserine lactones (AHLs), which are autoinducer quorum-sensing molecules involved in the bacterial communication network, also...
Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(2):199-211
Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent...
Cell Metab. 2018;28(5):737-49 e4
The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota...
Nat Commun. 2018;9(1):2802
Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly...
