Latest publications

Publication of various scientific studies

August 20 - 2020

Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells (Équipe Corvol)

BioRxiv The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce...
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July 31 - 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19 (Équipe Dorothée)

Nat Rev Immunol. 2020;20(9):515-6 The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species...
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July 14 - 2020

Identification of TGFbeta signatures in six murine models mimicking different osteoarthritis clinical phenotypes (Équipe Berenbaum)

Osteoarthritis Cartilage. 2020;28(10):1373-84 OBJECTIVE : TGFbeta is a key player in cartilage homeostasis and OA pathology. However, few data are available on the role of TGFbeta...
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July 10 - 2020

Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- alpha inhibition (Équipe Mohty )

Acta Pharm Sin B. 2020;10(6):1061-72 Arsenic trioxide (As2O3) is recently found to have therapeutic potential in systemic sclerosis (SSc), a life-threatening multi-system fibrosing...
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July 09 - 2020

The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis (Équipe Berenbaum)

Arthritis Rheumatol. 2020 OBJECTIVE : The non-neuronal cholinergic system represents non-neuronal cells that have the biochemical machinery to synthetize de novo and/or respond to...
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July 03 - 2020

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages (Équipe Seksik - Sokol)

Cell Host Microbe. 2020;28(3):390-401 e5 The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the...
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June 24 - 2020

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? (Équipe Corvol)

Front Immunol. 2020;11:1229 COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome....
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June 04 - 2020

Plasmacytoid dendritic cell biology and its role in immune-mediated diseases (Équipe Mohty)

Clin Transl Immunology. 2020;9(5):e1139 Plasmacytoid dendritic cells (pDCs) are a unique subset of dendritic cells specialised in secreting high levels of type I interferons. pDCs play a...
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June 01 - 2020

Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus (Équipe Sabbah)

bioRxiv 2020 There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...
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June 01 - 2020

Clearing method for 3-dimensional immunofluorescence of osteoarthritic subchondral human bone reveals peripheral cholinergic nerves (Équipe Berenbaum)

Sci Rep. 2020;10(1):8852 The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA)...
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France

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