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May 06 - 2021

Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus (Équipe Sabbah) Olivier Terrier, Sebastien Dilly, Andres Pizzorno, Dominika Chalupska, Jana Humpolickova, Evzen Boura, Francis Berenbaum, Stephane Quideau, Bruno Lina, Bruno Feve, Frederic Adnet, Michele Sabbah, Manuel Rosa-Calatrava, Vincent Marechal, Julien Henri, Anny Slama-Schwok

Molecules 26 (2021) There is an urgent need for specific antiviral treatments directed against SARS-CoV-2 to prevent the most severe forms of COVID-19. By drug repurposing, affordable...

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BOCCARA Franck

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May 14 - 2020

BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction (Équipe Sabbah) Géraldine Vilmen, Damien Glon, Gabriel Siracusano, Marion Lussignol, Zhouwulin Shao, Eva Hernandez, Daniel Perdiz, Frédérique Quignon, Lina Mouna, Christian Pous, Henri Gruffat, Vincent Maréchal, Audrey Esclatine

Autophagy 17 (2021): 1296-1315 Mitochondria respond to many cellular functions and act as central hubs in innate immunity against viruses. This response is notably due to their role in the...

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BOISSAN Mathieu

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May 08 - 2021

Several forms of SARS-CoV-2 RNA can be detected in wastewaters: Implication for wastewater-based epidemiology and risk assessment (Équipe Sabbah) S. Wurtzer, P. Waldman, A. Ferrier-Rembert, G. Frenois-Veyrat, J M. Mouchel, M. Boni, Y. Maday, V. Marechal, L. Moulin

Water Res 198 (2021): 117183 The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a public...

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BONNIN Agnès

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February 12 - 2021

Tryptophan metabolites get the gut moving (Équipe Seksik - Sokol ) Nicolas Benech, Nathalie Rolhion, Harry Sokol

Cell Host Microbe. 2021;29(2):145-7 How gut microbes can regulate the enteric nervous system and gut-brain communications is a field of intense research. In this issue of Cell Host &...

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BORDE Chloé

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July 08 - 2021

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal gammadelta T cells (Équipe Seksik - Sokol / Équipe Netchine) Louise Dupraz, Aurélie Magniez, Nathalie Rolhion, Mathias L. Richard, Gregory Da Costa, Sothea Touch, Camille Mayeur, Julien Planchais, Allison Agus, Camille Danne, Chloé Michaudel, Madeleine Spatz, Francois Trottein, Philippe Langella, Harry Sokol, Marie-Laure Michel

Cell Rep. 2021;36(1):109332 Gut interleukin-17A (IL-17)-producing gammadelta T cells are tissue-resident cells that are involved in both host defense and regulation of intestinal...

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March 10 - 2021

SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota (Équipe Seksik - Sokol) Harry Sokol, Vanessa Contreras, Pauline Maisonnasse, Aurore Desmons, Benoît Delache, Valentin Sencio, Arnaud Machelart, Angela Brisebarre, Lydie Humbert, Lucie Deryuter, Émilie Gauliard, Séverine Heumel, Dominique Rainteau, Nathalie Dereuddre-Bosquet, Élisabeth Menu, Raphaël Ho Tsong Fang, Antonin Lamazière, Loïc Brot, Céline Wahl, Cyriane Œuvray, Nathalie Rolhion, Sylvie Van Der Werf, Stéphanie Ferreira, Le Grand, Roger, Francois Trottein

Gut Microbes. 2021;13(1):1-19 The current pandemic of coronavirus disease (COVID) 2019 constitutes a global public health issue. Regarding the emerging importance of the gut-lung axis in...

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BORELAND William

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April 29 - 2021

Recipient factors in faecal microbiota transplantation: one stool does not fit all (Équipe Seksik - Sokol) Camille Danne, Nathalie Rolhion, Harry Sokol

Nat Rev Gastroenterol Hepatol. 2021 Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases associated with gut microbiota alterations. FMT cures 90% of...

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June 01 - 2020

Clearing method for 3-dimensional immunofluorescence of osteoarthritic subchondral human bone reveals peripheral cholinergic nerves (Équipe Berenbaum) Alice Courties, Morgane Belle, Simge Senay, Adeline Cambon-Binder, Alain Sautet, Alain Chédotal, Francis Berenbaum, Jérémie Sellam

Sci Rep. 2020;10(1):8852 The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA)...

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July 09 - 2020

The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis (Équipe Berenbaum) Alice Courties, Ariane Do, Sarah Leite, Manon Legris, Laure Sudre, Audrey Pigenet, Juliette Petit, Geoffroy Nourissat, Adeline Cambon-Binder, Uwe Maskos, Francis Berenbaum, Jeremie Sellam

Arthritis Rheumatol. 2020 OBJECTIVE : The non-neuronal cholinergic system represents non-neuronal cells that have the biochemical machinery to synthetize de novo and/or respond to...

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BOUMENDIL Ariane

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September 16 - 2020

Recommendations of the French Society of Rheumatology on pharmacological treatment of knee osteoarthritis (Équipe Berenbaum) Jeremie Sellam, Alice Courties, Florent Eymard, Stephanie Ferrero, Augustin Latourte, Paul Ornetti, Bernard Bannwarth, Laurence Baumann, Francis Berenbaum, Xavier Chevalier, Hang Korng Ea, Marie-ChristineFabre, Romain Forestier, Laurent Grange, Henri Lellouche, Jeremy Maillet, Didier Mainard, Serge Perrot, Francois Rannou, Anne-Christine Rat, Christian H. Roux, Eric Senbel, Pascal Richette

Joint Bone Spine. 2020 OBJECTIVES : To establish recommendations for pharmacological treatment of knee osteoarthritis specific to France. METHODS : On behalf of the French Society of...

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July 14 - 2020

Identification of TGFbeta signatures in six murine models mimicking different osteoarthritis clinical phenotypes (Équipe Berenbaum) M. Maumus, D. Noël, H.K. Ea, D. Moulin, M. Ruiz, E. Hay, X. Houard, D. Cleret, M. Cohen-Solal, C. Jacques, J.-Y. Jouzeau, M.-H. Lafage-Proust, P. Reboul, J. Sellam, C. Vinatier, F. Rannou, C. Jorgensen, J. Guicheux a, F. Berenbaum

Osteoarthritis Cartilage. 2020;28(10):1373-84 OBJECTIVE : TGFbeta is a key player in cartilage homeostasis and OA pathology. However, few data are available on the role of TGFbeta...

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March 17 - 2020

Activation of innate immunity by 14-3-3 epsilon, a new potential alarmin in osteoarthritis (Équipe Berenbaum) M. Millerand, L. Sudre, M. Nefla, F. Pène, C. Rousseau, A. Pons, A. Ravat, G. André-Leroux, S. Akira, T. Satoh, F. Berenbaum, C. Jacques

Osteoarthritis Cartilage. 2020;28(5):646-57 OBJECTIVE : The innate immune system plays a central role in osteoarthritis (OA). We identified 14-3-3epsilon as a novel mediator that guides...

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May 01 - 2020

Atypical presentation of COVID-19 in young infants (Équipe Corvol) Nadia Nathan, Blandine Prévost, Harriet Corvol

Lancet. 2020;395(10235):1481 As of April 27, 2020, more than two million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), with Europe being one of the current...

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BOUTROS Rita Maria

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August 20 - 2020

Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells (Équipe Corvol) Manon Ruffin, Jeanne Bigot, Claire Calmel, Harriet Corvol, Viviane Balloy, Loïc Guillot

BioRxiv The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce...

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BRAX Sylvain

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June 24 - 2020

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? (Équipe Corvol) Jean-Michel Sallenave, Loïc Guillot

Front Immunol. 2020;11:1229 COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome....

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July 31 - 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19 (Équipe Dorothée) Mireille Laforge, Carole Elbim, Corinne Frere, Miryana Hemadi, Charbel Massaad, Philippe Nuss, Jean-Jacques Benoliel, Chrystel Becker

Nat Rev Immunol. 2020;20(9):515-6 The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species...

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BREDON Marius

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February 26 - 2020

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis (Équipe Housset) Lynda Aoudjehane, Jérémie Gautheron, Wilfried Le Goff, Claire Goumard, Julia Gilaizeau, Chan Sonavine Nget, Éric Savier, Muhammad Atif, Philippe Lesnik, Romain Morichon, Yves Chrétien, Yvon Calmus, Olivier Scatton, Chantal Housset, Filomena Conti

Dis Model Mech. 2020;13(4) Normothermic perfusion provides a means to rescue steatotic liver grafts, including by pharmacological defatting. In this study, we tested the potential of new...

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BRIOUDE Frédéric

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March 15 - 2020

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease (Équipe Housset) Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien1, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron

J Hepatol. 2019 [Epub ahead of print] Background & Aims : In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death...

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