08/06/2026 - Sandrine RUCHAUD : Mitotic kinases as therapeutic targets: functional analysis and development of original inhibitors

LES LUNDIS DE SAINT-ANTOINE

Bâtiment Kourilsky - 11h–12h

Salle des Conférences (Rez de Chaussée),

184 rue du Faubourg Saint-Antoine, Paris

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LUNDI 08 JUIN 2026

Mitotic kinases as therapeutic targets: functional analysis and development of original inhibitors

Sandrine RUCHAUD

DR CNRS, Station Biologique de Roscoff

Invitée par Joëlle Sobczak équipe Joëlle Sobczack & Mathieu Boissan (joelle.sobczak@sorbonne-universite.fr)

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Our team work focuses on a group of key mitotic kinases both from a fundamental and a therapeutic point of view. Mostly, we have investigated the function and mechanism of action of the atypical Haspin kinase, a promising therapeutic target known for its role in cell division and its abnormally high expression in advanced-stage cancers.

Together with different medicinal chemistry, we developed specific heterocyclic inhibitors and degraders targeting Haspin. Using a combination of reverse genetics, chemobiology and chemogenetics approaches we identified a novel function of Haspin in autophagic regulation leading us to hypothesize that its overexpression in cancer cells may confer them a survival advantage.