Sorbonne Université - Faculty of medicine - Saint-Antoine Site – 10th floor
27, rue Chaligny - 75571 Paris cedex 12 - France
Our team is focused on immunological mechanism of action and side effects of immunotherapy and targeted therapy in the setting of hematological malignancies. In particular, we focus on allogeneic hematopoietic cell transplantation (allo-HCT) and graft-versus host reactions, CAR T-cells and monoclonal antibodies used for acute leukemia, lymphoma or multiple myeloma. We develop translational studies aiming to decipher the link between microbiota composition, immune system and clinical outcomes. Furthermore, we use in vitro experiments and animals’ models to identify the underlying mechanisms of action. Overall, these approaches are dedicated towards development of new therapeutic strategies based on immune modulation through gut microbiota manipulation to improve patients’ outcomes.
Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation. Malard F, Lavelle A, Battipaglia G, Gaugler B, Dulery R, Brissot E, Mediavilla C, Jegou S, Rolhion N, Ledraa T, Mohty R, Sokol H, Mohty M. Mucosal Immunol. 2021 Sep;14(5):1127-1132. doi: 10.1038/s41385-021-00429-z. Epub 2021 Jul 19. PMID: 34282272
Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients. Malard F, Vekhoff A, Lapusan S, Isnard F, D'incan-Corda E, Rey J, Saillard C, Thomas X, Ducastelle-Lepretre S, Paubelle E, Larcher MV, Rocher C, Recher C, Tavitian S, Bertoli S, Michallet AS, Gilis L, Peterlin P, Chevallier P, Nguyen S, Plantamura E, Boucinha L, Gasc C, Michallet M, Dore J, Legrand O, Mohty M. Nat Commun. 2021 May 25;12(1):3084. doi: 10.1038/s41467-021-23376-6. PMID: 34035290
Venetoclax does not impair activated T-cell proliferation. Siblany L, Gaugler B, Stocker N, Ricard L, Ye Y, Mohty M, Malard F. Bone Marrow Transplant. 2021 Jul;56(7):1740-1742. doi: 10.1038/s41409-021-01245-6. Epub 2021 Mar 8. PMID: 33686250
High-dose post-transplant cyclophosphamide impairs γδ T-cell reconstitution after haploidentical haematopoietic stem cell transplantation using low-dose antithymocyte globulin and peripheral blood stem cell graft. Stocker N, Gaugler B, Labopin M, Farge A, Ye Y, Ricard L, Brissot E, Duléry R, Sestili S, Battipaglia G, Médiavilla C, Paviglianiti A, Banet A, Van De Wyngaert Z, Ledraa T, Mohty M, Malard F. Clin Transl Immunology. 2020 Sep 23;9(9):e1171. doi: 10.1002/cti2.1171. eCollection 2020. PMID: 33005413
Daratumumab prevents programmed death ligand-1 expression on antigen-presenting cells in de novo multiple myeloma. Stocker N, Gaugler B, Ricard L, de Vassoigne F, Marjanovic Z, Mohty M, Malard F. Cancer Med. 2020 Mar;9(6):2077-2084. doi: 10.1002/cam4.2827. Epub 2020 Jan 28. PMID: 31991058
Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib. Ricard L, Jachiet V, Malard F, Ye Y, Stocker N, Rivière S, Senet P, Monfort JB, Fain O, Mohty M, Gaugler B, Mekinian A. Ann Rheum Dis. 2019 Apr;78(4):539-550. doi: 10.1136/annrheumdis-2018-214382. Epub 2019 Feb 13. PMID: 30760472
INSERM
Kourilsky Building
34 rue Crozatier - 75012 Paris
France
Sorbonne Université Medicine
Saint-Antoine Site
27 rue Chaligny - 75012 Paris
France
