• Monday, 19 August 2019 - 17:17:32

Director's word

feve-bruno.jpgThe Centre de Recherche Saint-Antoine (CRSA) has been created by the National Institute for Health and Medical Research (INSERM), and the Pierre and Marie Curie University (UPMC) on January 1st, 2008. It was directed by Professor Jacqueline Capeau until December 31, 2013; and initially includes 9 research teams. For the 2014-2018 period, 14 teams were approved by INSERM and UPMC.

Our research center is conceived to optimize the major translational research potential of the groups in the rapidly moving areas of onco-hematology and metabolism-inflammation. The CRSA connects investigators from a wide spectrum of skills that includes cellular and molecular biology, preclinical experimentation in whole animals, investigator-initiated clinical research, and translational research that brings discoveries from the bench to the bedside.

Our teams are thus organized around two main areas, onco-hematology, and metabolism-inflammation. They generally conduct projects spanning basic biology to integrated preclinical and clinical physiology, pathophysiology, and therapeutics. The research programs in onco-hematology are mainly focused on digestive, gynecologic, and skin cancers, in vitro erythropoiesis, leukemogenesis, and graft versus host disease. The teams in the metabolism-inflammation area have major interests on hepatic and biliary inflammatory diseases, adipose tissue diseases and the related comorbidities, pathophysiology of arthritis in relationship with metabolic diseases, Alzheimer’s disease, IGF1 signaling and associated growth and cardiometabolic disorders, and cystic fibrosis. 12 among these 14 teams are working in close partnership with clinical and biological departments of Saint-Antoine, Trousseau, and Tenon hospitals. They are located on two main buildings (Faculty and Kourilsky buildings) on about 8000 square meters.

The staff of the CRSA includes 32 permanent researchers, 89 university-hospital affiliated faculty, 27 hospital practitioners, 15 post-doctoral fellows, 44 PhD students, 45 permanent technical assistants, 30 non-permanent technical assistants, and 31 undergraduates.

The teams benefit from a common administrative unit, L1, L2, and L3 culture rooms, and high level small animal housing facilities. Otherwise, we have a privileged access to other technologies in strong connection with dedicated platforms for cell imaging, histology, flow cytometry (UMS 30 LUMIC), and biostatistics and bioinformatics platforms (UMS 29 OMICS).

Welcome to the Saint-Antoine Research Center!!

Pr Bruno Fève, director of CDRSA

Centre de Recherche (CdR) Saint-Antoine INSERM - UMR S 938

Hôpital St-Antoine


Tel : +(33) 1 49 28 46 87

Saint-Antoine Research Center
The CRSA was renewed jointly by Inserm and UPMC as UMRS_938, for 5 years from January 2014 to December 2018.
Presentation of the Centre

The CRSA regroups a very strong potential for biomedical research oriented towards both fundamental and translational research. Research is performed in association with the clinical and biological departments of the Saint-Antoine-Tenon-Armand Trousseau hospitals belonging to the same General Hospital Group. The CRSA is composed of 13 accredited research teams and one administrative team located mainly on the site of the Saint-Antoine hospital but also of hospital Armand Trousseau.

Scientific activities

Two scientific interacting orientations are identified: Research in Oncology and Haematology; and Research in Metabolism and Inflammation and Tissue Repair. They include several aspects of translational research : Fundamental; Preclinical; Pathophysiological and Aspects more specifically clinical.

Collective facilities and technological platforms

The Research Centre developed collective facilities (such as L2, L3 laboratories) but is also implicated in UPMC networks (for technologies such as Mass spectrometry, lipidomic and proteomic; Cell and tissue imagery and flow cytometry ; Imagery and functional exploration of small animals)