Thesis: Lin Lei – Identification and characterization of the progenitors of portal myofibroblasts
January 01 - 2020
directed by Chantal Housset & Axelle Cadoret
Myofibroblastic activation of star cells in the liver has long been considered the main mechanism of hepatic fibrogenesis. The team's work made it possible to identify portal myofibroblasts, a subpopulation of myofibroblasts derived from the mesenchyma of door spaces, characterized by the synthesis of collagen XV (Col15), intense proliferation and proangiogenic activity. These cells would have a decisive role in the evolution of hepatic fibrosis, which progresses from the portal space in connection with the formation of a vascular plexus leading to cirrhosis. The objective is to isolate and characterize the progenitors of portal myofibroblasts.