Hopital Saint-Antoine - Bâtiment Kourilsky - 5ème étage - 184, rue du Faubourg Saint-Antoine, 75012 Paris, France
Epigenetic, genetic and environmental factors are involved in the regulation of growth. Any disturbance affecting one of these factors can lead to abnormal growth in either fetal and/or postnatal periods. Intra-uterine growth retardation (IUGR) is associated with severe morbidity and mortality, and especially an enhanced metabolic risk. On the other hand, overgrowth syndromes are associated to an enhanced risk of tumor during childhood. Fetal and/or early postnatal alterations lead to a differential growth trajectory and to an alteration of energetic metabolism. We demonstrated in mice that nutrition during lactation can stimulate growth and program the adult size through a different setting of the neuroendocrine somatotropic axis. This is associated with a different sensitivity to develop cardio-metabolic pathologies in adulthood. Our goals, detailed in four axes below, are to improve the early detection of abnormal fetal growth and tumors-risk, understand the regulation of growth and metabolism in order to propose and help in the design for new treatment strategies to improve growth, metabolic and tumoral prognosis.