The Centre de Recherche Saint-Antoine (CRSA) has been created by the National Institute for Health and Medical Research (INSERM), and the Pierre and Marie Curie University (UPMC) on January 1st, 2008. It was directed by Professor Jacqueline Capeau until December 31, 2013; and initially includes 9 research teams. For the 2014-2018 period, 14 teams were approved by INSERM and UPMC.
Our research center is conceived to optimize the major translational research potential of the groups in the rapidly moving areas of onco-hematology and metabolism-inflammation. The CRSA connects investigators from a wide spectrum of skills that includes cellular and molecular biology, preclinical experimentation in whole animals, investigator-initiated clinical research, and translational research that brings discoveries from the bench to the bedside.
Our teams are thus organized around two main areas, onco-hematology, and metabolism-inflammation. They generally conduct projects spanning basic biology to integrated preclinical and clinical physiology, pathophysiology, and therapeutics. The research programs in onco-hematology are mainly focused on digestive, gynecologic, and skin cancers, in vitro erythropoiesis, leukemogenesis, and graft versus host disease. The teams in the metabolism-inflammation area have major interests on hepatic and biliary inflammatory diseases, adipose tissue diseases and the related comorbidities, pathophysiology of arthritis in relationship with metabolic diseases, Alzheimer’s disease, IGF1 signaling and associated growth and cardiometabolic disorders, and cystic fibrosis. 12 among these 14 teams are working in close partnership with clinical and biological departments of Saint-Antoine, Trousseau, and Tenon hospitals. They are located on two main buildings (Faculty and Kourilsky buildings) on about 8000 square meters.
The staff of the CRSA includes 32 permanent researchers, 89 university-hospital affiliated faculty, 27 hospital practitioners, 15 post-doctoral fellows, 44 PhD students, 45 permanent technical assistants, 30 non-permanent technical assistants, and 31 undergraduates.
The teams benefit from a common administrative unit, L1, L2, and L3 culture rooms, and high level small animal housing facilities. Otherwise, we have a privileged access to other technologies in strong connection with dedicated platforms for cell imaging, histology, flow cytometry (UMS 30 LUMIC), and biostatistics and bioinformatics platforms (UMS 29 OMICS).