184 rue du Faubourg Saint-Antoine - 75012, Paris
+(33)1 49 28 46 00
Common facilities and transversal activities
Oncology - Hematology Department
Metabolism - Inflammation Department
Spectrométrie de masse
Life of the center
Monday, 19 October 2020 - 17:54:24
Publication of various scientific studies
April 10 - 2018
Influence of Progenitor-Derived Regeneration Markers on Hepatitis C Virus-Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort) (Team Prunier)
Hepatology. 2018;68(4):1534-48 Progenitor-derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule...
April 07 - 2018
Aryl hydrocarbon receptor and intestinal immunity (Équipe Seksik/Sokol)
Mucosal Immunol. 2018;11(4):1024-38 Aryl hydrocarbon receptor (AhR) is a member of the basic helix-loop-helix-(bHLH) superfamily of transcription factors, which are associated with cellular...
March 27 - 2018
Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives (Team Fève)
Nucleus. 2018;9(1):235-48 Mutations in LMNA, encoding A-type lamins, are responsible for laminopathies including muscular dystrophies, lipodystrophies, and premature ageing syndromes. LMNA...
March 23 - 2018
The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development (Team Prunier)
Nat Commun. 2018;9(1):1216 Transforming growth factor-beta (TGFbeta) signaling is initiated by the type I, II TGFbeta receptor (TbetaRI/TbetaRII) complex. Here we report the formation of an...
March 04 - 2018
Mucosa-associated microbiota dysbiosis in colitis associated cancer (Team Seksik/Sokol)
Gut Microbes. 2018;9(2):131-42 Gut microbiota dysbiosis has been associated with inflammatory bowel diseases (IBD). In colorectal cancer, the gut microbiota has also been recognized as...
March 01 - 2018
FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition (Team Corvol, Prunier)
J Cyst Fibros. 2018;17(2):190-203 Background : Cystic fibrosis (CF) lung disease severity is highly variable and dependent on several factors including genetic modifiers. Family with...
March 01 - 2018
The extracellular domain of Her2 in serum as a biomarker of breast cancer (Team Prunier)
Lab Invest. 2018;98(6):696-707 Breast cancer is a major health problem worldwide. In ~15% of breast cancers, the epidermal growth factor receptor HER2, a transmembrane protein, is...
March 01 - 2018
Glycerolipid analysis during desiccation and recovery of the resurrection plant Xerophyta humilis (Bak) Dur and Schinz (Team Seksik/Sokol)
Plant Cell Environ. 2018;41(3):533-47 Xerophyta humilis is a poikilochlorophyllous monocot resurrection plant used as a model to study vegetative desiccation tolerance. Dehydration imposes...
Febuary 16 - 2018
The NDPK/NME superfamily: state of the art (Team Prunier)
Lab Invest. 2018;98(2):164-74 Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by NME genes (also called NM23). Given the fact that not all NME-encoded...
Febuary 01 - 2018
Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation (Team Prunier)
Cancer Res. 2018;78(3):659-70 Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated...
Febuary 01 - 2018
Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epithelial cells (Team Seksik/Sokol)
Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(2):199-211 Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent...
January 29 - 2018
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement. (Team Netchine)
Nat Rev Endocrinol. 2018;14(4):229-49 Beckwith–Wiedemann syndrome (BWS), a human genomic imprinting disorder, is characterized by phenotypic variability that might include overgrowth,...
December 09 - 2017
Chromosomal rearrangements in the 11p15 imprinted region: 17 new 11p15.5 duplications with associated phenotypes and putative functional consequences (Team Netchine)
Med Genet. 2018;55(3):205-13 Background : The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth...
December 01 - 2017
Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus: impact on production of lipo-viro-particles (Team Seksik/Sokol)
Gut. 2017;66(12):2160-9 Objective : HCV is intimately linked with the liver lipid metabolism, devoted to the efflux of triacylglycerols stored in lipid droplets (LDs) in the form of...
November 10 - 2017
Calibrated mitotic oscillator drives motile ciliogenesis (Team Prunier)
Science. 2017;358(6364):803-6 Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase...
November 06 - 2017
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons (Team Holzenberger)
Brain. 2017;140(7):2012-27 Seminal studies using post-mortem brains of patients with Alzheimer's disease evidenced aberrant insulin-like growth factor 1 receptor (IGF1R) signalling....
November 01 - 2017
Dysregulation of the anti-müllerian hormone system by steroids in women with polycystic ovary syndrome (Team Fève)
J Clin Endocrinol Metab. 2017;102(11):3970-8 Context : Anti-Mullerian hormone (AMH) and AMH type II receptor (AMHR2) are overexpressed in granulosa cells (GCs) from women with polycystic...
October 01 - 2017
Role of the autonomic nervous system in osteoarthritis (Team Berenbaum)
Best Pract Res Clin Rheumatol. 2017;31(5):661-75 Joint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular...
September 05 - 2017
Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction (Team Holzenberger)
Proc Natl Acad Sci U S A. 2017;114(36):9731-6 When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive...
September 04 - 2017
Low levels of microsatellite instability at simple repeated sequences commonly occur in human hepatocellular carcinoma (Team Prunier)
Cancer Genomics Proteomics. 2017;14(5):329-39 Background/Aim : The aim of this study was to assess the incidence of MSI in a large series of human hepatocellular carcinomas (HCC) with...
August 10 - 2017
Genetic disruption of the oncogenic HMGA2–PLAG1–IGF2 pathway causes fetal growth restriction (Team Netchine)
Genet Med. 2018;20(2):250-8 Purpose : Fetal growth is a complex process involving maternal, placental and fetal factors. The etiology of fetal growth retardation remains unknown in many...
July 18 - 2017
The advantage of channeling nucleotides for very processive functions (Team Prunier)
F1000Res. 2017;6:724 Nucleoside triphosphate (NTP)s, like ATP (adenosine 5'-triphosphate) and GTP (guanosine 5'-triphosphate), have long been considered sufficiently concentrated and...
July 11 - 2017
Regulation of growth: Epigenetic mechanisms? (Team Netchine)
Ann Endocrinol (Paris). 2017;78(2):92-5 Abstract Organism development is controlled by both genetic programs and the environment to insure a reproductive success as adults. Linear...
July 01 - 2017
Disrupting IGF signaling in adult mice conditions leanness, resilient energy metabolism, and high growth hormone pulses (Team Holzenberger)
Endocrinology. 2017;158(7):2269-83 Growth hormone (GH) and insulin-like growth factor (IGF) promote aging and age-related pathologies. Inhibiting this pathway by targeting IGF receptor...
July 01 - 2017
Expression patterns of nuclear receptors in parenchymal and non-parenchymal mouse liver cells and their modulation in cholestasis (Team Housset)
Biochim Biophys Acta Mol Basis Dis. 2017;1863(7):1699-708 Nuclear receptors (NR), the largest family of transcription factors, control many physiological and pathological processes. To gain...
June 22 - 2017
Induced pluripotent stem cell-derived limbal epithelial cells (LiPSC) as a cellular alternative for in vitro ocular toxicity testing (Team Prunier)
PLoS One. 2017;12(6):e0179913 Induced pluripotent stem cells hold great potential to produce unlimited amount of differentiated cells as cellular source for regenerative medicine but also...
June 01 - 2017
Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells (Team Fève)
Diabetes. 2017;66(6):1470-8 Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige...
June 01 - 2017
Fungal microbiota dysbiosis in IBD (Team Seksik/Sokol)
Gut. 2017;66(6):1039-48 Objective : The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD...
May 11 - 2017
WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity (Team Larsen/Sabbah)
Sci Rep. 2017;7(1):1749 WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the CCN family able to mediate cell growth, transformation and survival in a...
April 15 - 2017
LMNA-associated partial lipodystrophy: anticipation of metabolic complications (Team Fève)
J Med Genet. 2017;54(6):413-6 Background : Type-2 familial partial lipodystrophy (FPLD2) is a rare autosomal dominant lipodystrophic disorder due to mutations in LMNA encoding lamin A/C, a...
Phone : +(33) 1 49 28 46 00