184 rue du Faubourg Saint-Antoine - 75012, Paris
+(33)1 49 28 46 00
Common facilities and transversal activities
Oncology - Hematology Department
Metabolism - Inflammation Department
Spectrométrie de masse
Life of the center
Monday, 19 October 2020 - 18:08:20
Publication of various scientific studies
Febuary 01 - 2019
Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure (Team Fève)
Diabetes. 2019;68(2):305-17 Widely used for their anti-inflammatory and immunosuppressive properties, glucocorticoids are nonetheless responsible for the development of diabetes and...
January 11 - 2019
Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis (Team Berenbaum)
Arthritis Res Ther. 2019;21(1):18 Background : Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme...
January 10 - 2019
Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential (Team Seksik/Sokol)
Toxicol Sci. 2019;168(2):474-85 Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile...
January 01 - 2019
Adaptive beta-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance (Team Fève)
Diabetes. 2019;68(1):95-108 Both type 1 and type 2 diabetes are characterized by deficient insulin secretion and decreased beta-cell mass. Thus, regenerative strategies to increase...
January 01 - 2019
Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration (Team Fève)
J Steroid Biochem Mol Biol. 2019;185:150-62 Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs....
December 22 - 2018
The Phenotypic Approach to Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis (Team Berenbaum)
Joint Bone Spine. 2018 Metabolic syndrome-associated osteoarthritis (Met-OA) is a clinical phenotype defined by the role of obesity and metabolic syndrome as risk factors and by chronic...
December 19 - 2018
LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis (Team Housset)
Aliment Pharmacol Ther. 2019;49(3):308-20 Background : No blood test has been shown to be effective in the prediction of primary liver cancer in patients without cirrhosis. AIM: To...
December 01 - 2018
Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice (Team Housset - Seksik/Sokol)
Hepatol Commun. 2018;2(12):1533-49 The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the...
November 06 - 2018
Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome (Team Seksik/Sokol)
Cell Metab. 2018;28(5):737-49 e4 The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota...
November 01 - 2018
Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Team Seksik/Sokol)
Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...
October 22 - 2018
Mixed signals from the cell's antennae: primary cilia in cancer (Team Seksik/Sokol)
EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
October 08 - 2018
Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression (Team Housset)
Biophys Acta Mol Basis Dis. 2018;1864(12):3688-96 Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal...
October 01 - 2018
Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence (Team Seksik/Sokol)
Gut. 2018;67(10):1836-44 Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
September 12 - 2018
Modern-day environmental factors in the pathogenesis of osteoarthritis (Team Berenbaum)
Nat Rev Rheumatol. 2018;14(11):674-81 The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this Opinion article, we review the possibility that OA...
September 11 - 2018
Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Team Seksik/Sokol)
J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
August 29 - 2018
Inter-kingdom effect on epithelial cells of the N-Acyl homoserine lactone 3-oxo-C12:2, a major quorum-sensing molecule from gut microbiota (Team Seksik/Sokol)
PLoS One. 2018;13(8):e0202587 Background and Aims : N-acyl homoserine lactones (AHLs), which are autoinducer quorum-sensing molecules involved in the bacterial communication network, also...
August 02 - 2018
Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation (Team Holzenberger)
Int J Cancer. 2018;143(10):2458-69 Insulin and insulin-like growth factor (IGF)-1 signaling in the thyroid are thought to be permissive for the coordinated regulation by thyroid-stimulating...
August 01 - 2018
Diagnosis and management of postnatal fetal growth restriction (Team Netchine)
Best Pract Res Clin Endocrinol Metab. 2018;32(4):523-34 Fetal growth restriction (FGR) can result from multiple causes, such as genetic, epigenetic, environment, hormonal regulation, or...
July 25 - 2018
MFN2-associated lipomatosis: Clinical spectrum and impact on adipose tissue (Team Fève)
J Clin Lipidol. 2018;12(6):1420-35 Background : Multiple symmetric lipomatosis (MSL) is characterized by upper-body lipomatous masses frequently associated with metabolic and neurological...
July 18 - 2018
Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice (Team SeksikSokol)
Nat Commun. 2018;9(1):2802 Dietary lipids favor the growth of the pathobiont Bilophila wadsworthia, but the relevance of this expansion in metabolic syndrome pathogenesis is poorly...
July 09 - 2018
Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes (Team Seksik/Sokol)
J Pathol. 2018;246(2):217-30 Obesity and its metabolic complications are characterized by subclinical systemic and tissue inflammation. In rodent models of obesity, inflammation and...
June 18 - 2018
Twist1 activation in muscle progenitor cells causes muscle loss akin to cancer cachexia (Team Prunier)
Dev Cell. 2018;45(6):712-25 e6 Cancer cachexia is characterized by extreme skeletal muscle loss that results in high morbidity and mortality. The incidence of cachexia varies among tumor...
June 13 - 2018
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease (Team Seksik/Sokol)
Cell Host Microbe. 2018;23(6):716-24 The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
June 07 - 2018
A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis (Team Housset)
N Engl J Med. 2018;378(23):2171-81 Background : Patients with primary biliary cholangitis who have an inadequate response to therapy with ursodeoxycholic acid are at high risk for disease...
May 29 - 2018
Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein (Team Prunier)
Stem Cells. 2018;36(9):1421-9 Heterozygous PAX6 gene mutations leading to haploinsufficiency are the main cause of congenital aniridia, a rare and progressive panocular disease...
May 15 - 2018
Intraflagellar transport is deeply integrated in hedgehog signaling (Team Seksik/Sokol)
Mol Biol Cell. 2018;29(10):1178-89 The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in...
May 03 - 2018
The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma (Team Housset)
Clin Cancer Res. 2018;24(17):4282-96 Purpose : Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and...
April 19 - 2018
The nuclear retinoid-related orphan receptor RORalpha controls circadian thermogenic programming in white fat depots (Team Fève)
Physiol Rep. 2018;6(8):e13678 The RORalpha-deficient staggerer (sg/sg) mouse is lean and resistant to diet-induced obesity. Its thermogenic activity was shown to be increased not only in...
April 15 - 2018
The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks (Team Fève)
Hum Mol Genet. 2018;27(8):1447-59 The p.R482W hotspot mutation in A-type nuclear lamins causes familial partial lipodystrophy of Dunnigan-type (FPLD2), a lipodystrophic syndrome complicated...
April 11 - 2018
Chromosome 14q32.2 Imprinted Region Disruption as an Alternative Molecular Diagnosis of Silver-Russell Syndrome (Team Netchine)
J Clin Endocrinol Metab. 2018;103(7):2436-46 Context : Silver-Russell syndrome (SRS) (mainly secondary to 11p15 molecular disruption) and Temple syndrome (TS) (secondary to 14q32.2...
Phone : +(33) 1 49 28 46 00