184 rue du Faubourg Saint-Antoine - 75012, Paris
+(33)1 49 28 46 00
Common facilities and transversal activities
Oncology - Hematology Department
Metabolism - Inflammation Department
Spectrométrie de masse
Life of the center
Monday, 19 October 2020 - 17:26:12
Publication of various scientific studies
August 20 - 2020
Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells (Team Corvol)
BioRxiv 2020 The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce...
June 24 - 2020
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets? (Team Corvol)
Front Immunol. 2020;11:1229 COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-2, an enveloped virus with a positive-polarity, single-stranded RNA genome....
June 01 - 2020
Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus (Team Sabbah)
bioRxiv 2020 There is an urgent need for specific antiviral drugs directed against SARS-CoV-2 both to prevent the most severe forms of COVID-19 and to reduce viral excretion and subsequent...
June 01 - 2020
Clearing method for 3-dimensional immunofluorescence of osteoarthritic subchondral human bone reveals peripheral cholinergic nerves (Team Berenbaum)
Sci Rep. 2020;10(1):8852 The cholinergic system plays a major anti-inflammatory role in many diseases through acetylcholine (Ach) release after vagus nerve stimulation. Osteoarthritis (OA) is...
May 01 - 2020
Atypical presentation of COVID-19 in young infants (Team Corvol)
Lancet. 2020;395(10235):1481 As of April 27, 2020, more than two million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), with Europe being one of the current...
March 15 - 2020
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease (Team Housset)
J Hepatol. 2019 [Epub ahead of print] Background & Aims: In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death...
December 19 - 2019
Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density (Teams Larsen/Sabbah – Fève – Seksik/Sokol)
Cancers (Basel). 2019;11(12) Breast adiposity is correlated with body mass index, menopausal status and mammary density. We here wish to establish how these factors influence the cross-talk...
November 30 - 2019
Contribution of adipocyte precursors in the phenotypic specificity of intra-articular adipose tissues in knee osteoarthritis patients (Team Berenbaum)
Arthritis Res Ther. 2019;21(1):252 Background : Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing...
November 03 - 2019
Respiratory Epithelial Cells Can Remember Infection: A Proof of Concept Study (Team Corvol)
J Infect Dis. 2019 Human bronchial epithelial cells play a key role in airway immune homeostasis. We hypothesized that these sentinel cells can remember a previous contact with pathogen...
October 28 - 2019
Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production (Team Seksik/Sokol)
Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(2):158530 The mechanisms leading to the low-grade inflammation observed during obesity are not fully understood. Seeking the initiating...
October 18 - 2019
Danger signals and inflammaging in osteoarthritis (Team Berenbaum)
Clin Exp Rheumatol. 2019;37 Suppl 120(5):48-56 Osteoarthritis (OA) is the most com- mon age-related chronic and disabling joint disease. Long considered to be a “wear and tear”...
October 07 - 2019
Increasing knowledge in IGF1R defects: lessons from 35 new patients (Team Netchine)
J Med Genet. 2019 Background : The type 1 insulin-like growth factor receptor (IGF1R) is a keystone of fetal growth regulation by mediating the effects of IGF-I and IGF-II. Recently, a...
September 24 - 2019
Genetic contribution of ABCC2 to Dubin-Johnson syndrome and inherited cholestatic disorders (Team Housset / Fève)
Liver Int. 2019 Background and aim s: The ABCC2 gene is implicated in Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver disorder. The primary aim of this study was to determine...
August 02 - 2019
Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host (Team Seksik/Sokol)
Microbiome. 2019;7(1):111 Background : Normal mammalian development and homeostasis are dependent upon the gut microbiota. Antibiotics, essential for the treatment and prophylaxis of...
June 27 - 2019
A mutation inactivating the distal SF1 binding site on the human anti-Mullerian hormone promoter causes persistent Mullerian duct syndrome (Team Fève)
Hum Mol Genet. 2019;28(19):3211-8 The persistent Mullerian duct syndrome (PMDS) is a 46,XY disorder of sexual development characterized by the persistence of Mullerian duct derivatives,...
June 15 - 2019
Sleep disordered breathing in Silver−Russell syndrome patients: A new outcome (Team Netchine)
Sleep Med. 2019;on line Objective ; Imprinting disorders (ID), such as Prader−Willi syndrome (PWS), are associated with sleep-disordered breathing (SDB). No data are available for...
May 01 - 2019
Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis (Team Fève)
AIDS. 2019;33(6):953-64 Objective : HIV-infected patients receiving antiretroviral treatment (ART) often present adipose tissue accumulation and/or redistribution. adipose tissue has been...
April 30 - 2019
Roles of Type 1 Insulin-Like Growth Factor (IGF) Receptor and IGF-II in Growth Regulation: Evidence From a Patient Carrying Both an 11p Paternal Duplication and 15q Deletion (Team Netchine)
Front Endocrinol (Lausanne). 2019;10:263 We report an original association of complex genetic defects in a patient carrying both an 11p paternal duplication, resulting in the double...
April 30 - 2019
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models (Team Housset)
Sci Rep. 2019;9(1):6653 Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of...
April 19 - 2019
Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis (Team Housset & Seksik-Sokol)
Gut. 2019 Objective : Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these...
April 15 - 2019
Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis (Team Prunier)
Dev Biol. 2019;448(2):237-46 At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ...
April 05 - 2019
Atmospheric pressure plasma jets applied to cancerology: correlating electrical configuration with in vivo toxicity and therapeutic efficiency (Team Housset)
Journal of Physics D: Applied Physics. 2019;52(24) Two atmospheric pressure plasma jet (APPJ) devices—a plasma gun and a plasma Tesla jet—are compared in terms of safety and...
March 15 - 2019
Simple Magnetic Resonance Scores Associate With Outcomes of Patients With Primary Sclerosing Cholangitis (Team Housset)
Clin Gastroenterol Hepatol. 2019 Background & Aims : Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in...
March 08 - 2019
Genetic effects on the commensal microbiota in inflammatory bowel disease patients (Team Seksik/Sokol)
PLoS Genet. 2019;15(3):e1008018 Several bacteria in the gut microbiota have been shown to be associated with inflammatory bowel disease (IBD), and dozens of IBD genetic variants have been...
March 06 - 2019
Overgrowth syndromes - clinical and molecular aspects and tumour risk (Team Netchine)
Nat Rev Endocrinol. 2019;15(5):299-311 Overgrowth syndromes are a heterogeneous group of rare disorders characterized by generalized or segmental excessive growth commonly associated with...
March 01 - 2019
The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases (Team Seksik/Sokol)
Nat Rev Gastroenterol Hepatol. 2019;16(6):331-45 The gut microbiota is a dense and diverse ecosystem that is involved in many physiological functions as well as in disease pathogenesis. It...
March 01 - 2019
Intestinal plasticity in response to nutrition and gastrointestinal surgery (Team Seksik/Sokol)
Nutr Rev. 2019;77(3):129-43 The plasticity of a material corresponds to its capacity to change its feature under the effect of an external action. Intestinal plasticity could be defined as...
Febuary 20 - 2019
Transcriptional profiling at DLK1/MEG3 domain explains clinical overlap between imprinting disorders (Team Netchine)
Sci. Adv. 2019; 5 : eaau9425 Clinical and molecular overlap in imprinting disorders Imprinting disorders (ID) often affect growth in humans, leading to diseases with overlapping...
Febuary 11 - 2019
SERPINA1 Z allele is associated with cystic fibrosis liver disease (Team Corvol)
Genetics in Medicine 2019 Purpose : The SERPINA1 Z allele is associated with cystic fibrosis (CF)-related liver disease (CFLD), a common manifestation in patients with CF. We estimated...
Febuary 07 - 2019
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function (Team Seksik/Sokol)
Gut. 2019 Objective : We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA...
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