184 rue du Faubourg Saint-Antoine - 75012, Paris
+(33)1 49 28 46 00
Common facilities and transversal activities
Oncology - Hematology Department
Metabolism - Inflammation Department
Spectrométrie de masse
Life of the center
Monday, 14 October 2019 - 11:25:37
Publication of various scientific studies
September 24 - 2019
Genetic contribution of ABCC2 to Dubin-Johnson syndrome and inherited cholestatic disorders (Team Housset / Fève)
Liver Int. 2019 Background and aim s: The ABCC2 gene is implicated in Dubin-Johnson syndrome (DJS), a rare autosomal recessive liver disorder. The primary aim of this study was to determine...
August 02 - 2019
Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host (Équipe Seksik/Sokol)
Microbiome. 2019;7(1):111 Background : Normal mammalian development and homeostasis are dependent upon the gut microbiota. Antibiotics, essential for the treatment and prophylaxis of...
June 15 - 2019
Sleep disordered breathing in Silver−Russell syndrome patients: A new outcome (Équipe Netchine)
Sleep Med. 2019;on line Objective ; Imprinting disorders (ID), such as Prader−Willi syndrome (PWS), are associated with sleep-disordered breathing (SDB). No data are available for...
May 01 - 2019
Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis (Équipe Fève)
AIDS. 2019;33(6):953-64 Objective : HIV-infected patients receiving antiretroviral treatment (ART) often present adipose tissue accumulation and/or redistribution. adipose tissue has been...
April 30 - 2019
Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models (Équipe Housset)
Sci Rep. 2019;9(1):6653 Adenosine triphosphate binding cassette transporter, subfamily B member 4 (ABCB4) is the transporter of phosphatidylcholine at the canalicular membrane of...
April 19 - 2019
Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis (Équipe Housset & Seksik-Sokol)
Gut. 2019 Objective : Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these...
April 15 - 2019
Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis (Équipe Prunier)
Dev Biol. 2019;448(2):237-46 At the onset of the Ciona intestinalis metamorphosis, the first event is tail regression characterized, by a contraction, an apoptotic wave and Primordial Germ...
April 05 - 2019
Atmospheric pressure plasma jets applied to cancerology: correlating electrical configuration with in vivo toxicity and therapeutic efficiency (Équipe Housset)
Journal of Physics D: Applied Physics. 2019;52(24) Two atmospheric pressure plasma jet (APPJ) devices—a plasma gun and a plasma Tesla jet—are compared in terms of safety and...
March 15 - 2019
Simple Magnetic Resonance Scores Associate With Outcomes of Patients With Primary Sclerosing Cholangitis (Équipe Housset)
Clin Gastroenterol Hepatol. 2019 Background & Aims : Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in...
March 08 - 2019
Genetic effects on the commensal microbiota in inflammatory bowel disease patients (Équipe Seksik/Sokol)
PLoS Genet. 2019;15(3):e1008018 Several bacteria in the gut microbiota have been shown to be associated with inflammatory bowel disease (IBD), and dozens of IBD genetic variants have been...
March 01 - 2019
The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases (Équipe Seksik/Sokol)
Nat Rev Gastroenterol Hepatol. 2019;16(6):331-45 The gut microbiota is a dense and diverse ecosystem that is involved in many physiological functions as well as in disease pathogenesis. It...
March 01 - 2019
Intestinal plasticity in response to nutrition and gastrointestinal surgery (Équipe Seksik/Sokol)
Nutr Rev. 2019;77(3):129-43 The plasticity of a material corresponds to its capacity to change its feature under the effect of an external action. Intestinal plasticity could be defined as...
Febuary 20 - 2019
Transcriptional profiling at DLK1/MEG3 domain explains clinical overlap between imprinting disorders (Équipe Netchine)
Sci. Adv. 2019; 5 : eaau9425 Clinical and molecular overlap in imprinting disorders Imprinting disorders (ID) often affect growth in humans, leading to diseases with overlapping...
Febuary 11 - 2019
SERPINA1 Z allele is associated with cystic fibrosis liver disease (Équipe Corvol)
Genetics in Medicine 2019 Purpose : The SERPINA1 Z allele is associated with cystic fibrosis (CF)-related liver disease (CFLD), a common manifestation in patients with CF. We estimated...
Febuary 07 - 2019
TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function (Équipe Seksik/Sokol)
Gut. 2019 Objective : We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled receptor highly expressed in biliary epithelial cells, protects the liver against BA...
Febuary 01 - 2019
Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure (Équipe Fève)
Diabetes. 2019;68(2):305-17 Widely used for their anti-inflammatory and immunosuppressive properties, glucocorticoids are nonetheless responsible for the development of diabetes and...
January 11 - 2019
Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis (Équipe Berenbaum)
Arthritis Res Ther. 2019;21(1):18 Background : Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme...
January 10 - 2019
Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential (Équipe Seksik/Sokol)
Toxicol Sci. 2019;168(2):474-85 Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile...
January 01 - 2019
Adaptive beta-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance (Équipe Fève)
Diabetes. 2019;68(1):95-108 Both type 1 and type 2 diabetes are characterized by deficient insulin secretion and decreased beta-cell mass. Thus, regenerative strategies to increase...
January 01 - 2019
Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration (Équipe Fève)
J Steroid Biochem Mol Biol. 2019;185:150-62 Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs....
December 22 - 2018
The Phenotypic Approach to Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis (Équipe Berenbaum)
Joint Bone Spine. 2018 Metabolic syndrome-associated osteoarthritis (Met-OA) is a clinical phenotype defined by the role of obesity and metabolic syndrome as risk factors and by chronic...
December 19 - 2018
LCR1 and LCR2, two multi-analyte blood tests to assess liver cancer risk in patients without or with cirrhosis (Équipe Housset)
Aliment Pharmacol Ther. 2019;49(3):308-20 Background : No blood test has been shown to be effective in the prediction of primary liver cancer in patients without cirrhosis. AIM: To...
December 01 - 2018
Diet-Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice (Équipes Housset - Seksik/Sokol)
Hepatol Commun. 2018;2(12):1533-49 The most typical expression of cystic fibrosis (CF)-related liver disease is a cholangiopathy that can progress to cirrhosis. We aimed to determine the...
November 06 - 2018
Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome (Équipe Seksik/Sokol)
Cell Metab. 2018;28(5):737-49 e4 The extent to which microbiota alterations define or influence the outcome of metabolic diseases is still unclear, but the byproducts of microbiota...
November 01 - 2018
Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis (Équipe Seksik/Sokol)
Aliment Pharmacol Ther. 2018;48(9):961-74 Background : Intestinal microbiota plays an important role in bile acid homeostasis. Aim : To study the structure of the intestinal microbiota...
October 22 - 2018
Mixed signals from the cell's antennae: primary cilia in cancer (Équipe Seksik/Sokol)
EMBO Rep. 2018;19(11) Primary cilia (PC) are antenna-like organelles that protrude from most mammalian cells. They are essential for the regulation of several signaling pathways such as...
October 08 - 2018
Endoplasmic reticulum stress induces inverse regulations of major functions in portal myofibroblasts during liver fibrosis progression (Équipe Housset)
Biophys Acta Mol Basis Dis. 2018;1864(12):3688-96 Portal myofibroblasts (PMF) form a sub-population of highly proliferative and proangiogenic liver myofibroblasts that derive from portal...
October 01 - 2018
Card9 mediates susceptibility to intestinal pathogens through microbiota modulation and control of bacterial virulence (Équipe Seksik/Sokol)
Gut. 2018;67(10):1836-44 Objective : In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment...
September 12 - 2018
Modern-day environmental factors in the pathogenesis of osteoarthritis (Équipe Berenbaum)
Nat Rev Rheumatol. 2018;14(11):674-81 The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this Opinion article, we review the possibility that OA...
September 11 - 2018
Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients (Équipe Seksik/Sokol)
J Lipid Res. 2018;59(11):2202-13 Bile acid (BA) secretion and circulation in chronic pancreatitis (CP) patients with exocrine pancreatic insufficiency (EPI) were investigated by...
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